T 5601640
T56-LIMKi
CAS: 924473-59-6
Molecular Formula: C19H14F3N3O3
T 5601640 - Names and Identifiers
T 5601640 - Physico-chemical Properties
| Molecular Formula | C19H14F3N3O3 |
| Molar Mass | 389.33 |
| Density | 1.426±0.06 g/cm3(Predicted) |
| Boling Point | 403.4±45.0 °C(Predicted) |
| Solubility | DMSO : 36 mg/mL (92.47 mM) |
| Appearance | powder |
| Color | white to beige |
| pKa | 11.41±0.70(Predicted) |
| Storage Condition | 2-8°C |
| In vitro study | T56-LIMKi efficiently inhibits the growth of ST88-14, U87, Panc-1 cells, A549 lung cancer cells with IC 50 values of 18.3, 7.4, 35.2 and 90 μM, respectively. T56-LIMKi decreases phosphorylated cofilin (p-cofilin) levels and thus inhibits growth of several cancerous cell lines, including those of pancreatic cancer, glioma and schwannoma. It blocks the phosphorylation of cofilin which leads to actin severance and inhibition of tumor cell migration, tumor cell growth, and anchorage-independent colony formation in soft agar. T56-LIMKi (10-50 μM) reduces p-cofilin in a dose-dependent manner in NF1 −/− MEFs with an IC 50 of 30 μM. Notably, the inhibitor does not affect the amounts of total cofil. 50μM T56-LIMKi causes a statistically significant reduction in the number of cells exhibiting stress fibers. |
| In vivo study | T56-LIMKi can induce inhibition of cofilin phosphorylation and Panc-1 tumor shrinkage in vivo . Mice treated with T56-LIMKi (60 mg/kg) shows a significant decrease in tumor volume compared to control. |
T 5601640 - Risk and Safety
| UN IDs | UN 2811 6.1 / PGIII |
T 5601640 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.569 ml | 12.843 ml | 25.685 ml |
| 5 mM | 0.514 ml | 2.569 ml | 5.137 ml |
| 10 mM | 0.257 ml | 1.284 ml | 2.569 ml |
| 5 mM | 0.051 ml | 0.257 ml | 0.514 ml |
Last Update：2024-01-02 23:10:35
T 5601640 - Reference Information
| biological activity | T56-LIMKi is a LIM kinase 2 (LIMK2) inhibitor that inhibits LIMK2-mediated phosphorylation of filamentous proteins. |
| Target | Value |
Last Update：2024-04-09 02:00:14
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Spot supply
Product Name: T56-LIMKi Visit Supplier Webpage Request for quotationCAS: 924473-59-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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